Target strategy
Pain sensation is a complex and highly coordinated process. In simplified terms, the pain signaling pathway can be divided into four key steps:
Transduction – the conversion of harmful stimuli into electrical signals;
Signal relay – the release of neurotransmitters and transfer of signals to spinal cord neurons;
Transmission – the propagation of these signals along sensory fibers;
Central perception – where the brain interprets these signals as pain.
Interrupting any of these key steps offers an opportunity for effective pain management.
Our Integrated Approach to the Discovery of Novel Analgesics
01
Core Science Based on lon Channels
- Longstanding expertise in Naᵥ1.7 (erythromelalgia)
- Robust ion channel drug discovery platform
- Integrated in-house preclinical validation platforms
02
Best-in-class/First-in-class Therapeutics
- Naᵥ1.8 inhibitors with superior competitive advantages
- Dual inhibitor targeting Naᵥ1.7/ Naᵥ1.8 and combination therapy for enhanced analgesia
03
Competitive lon Channel Drug Discovery Platform
- Structurally diverse, high quality chemical library for ion channel targets
- Cryo-EM-based structural biology, SBDD and LBDD drug design and optimization
- Fast DMTA cycle to ensure the delivery of high-quality compounds
04
Integrated In-house Preclinical Validation Platforms
- In house capacity for hNaᵥs evaluation
- Internal DRG neuronal electrophysiology assessment for rat and cyno
- Multiple in-house in vivo pain models in rodents
Pipeline Overview
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